Journal of Bioequivalence & Bioavailability

Multiparticulate drug delivery system: Formulation of esmoprazole magnesium oral delayed release pellets

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Vinod P. Dube, Avinash A. Hosmani and John I. D?souza

Posters: J Bioequiv Availab

Abstract:

Multiparticulate drug delivery system creates tremendous opportunity for designing new controlled and delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time hence extending the frontier of future pharmaceutical development. The present work was conceded with an objective to study multiparticulate of Esmoprazole magnesium and to study its invitro behavior. The pellets of Esmoprazole magnesium were prepared by drug loading process by using conventional coating pan technique using sugar as base and HPMCE5 as binder solution. The pellets were coated with HPMC E5 and mannitol as barrier coating, mannitol was used as solubliser to give burst release. The pellets were coated with Eudragit L30 D55 or L55100 in order to provide delayed release of drug in intestine. The prepared pellets were evaluated for drug content, friability, particle size analysis, in-vitro disintegration time and drug release study. The pellets were evaluated by differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) to study the stability of drug in the carrier system. The invitro release studies of developed pellets indicated the delayed release as there was NMT 5% release in acid to ensure or avoid loss of drug in stomach. The result was analyzed by applying factorial design and the formulated pellet release it?s all drug in intestine within 1 hour. In conclusion, Faster dissolution was achieved in 6.8 phosphate buffer as like innovator (from literature) to give bioequivalent product and the multiparticulates of Esmoprazole magnesium coated with eudragits were improving bioavailability successfully and can be beneficial for gastritis