Journal of Surgery and Anesthesia

MRI report post neoadjuvant chemoradiotherapy for advanced rectal cancer can help reduce the rate of surgery for locally advanced rectal cancer

8^th International Conference on Surgery and Anaesthesia

April 05-06, 2023 | Webinar

Onyekachi Ekowo

Darent Valley Hospital, United Kingdom

Scientific Tracks Abstracts: J Surg Anesth

Abstract:

Aim: A study to investigate the tumour behaviour in the management of locally advanced rectal cancer (LARC) treated with neoadjuvant chemo-radiotherapy (NACRT) and definitive surgery to help guide decision on watchful wait versus surgery post NACRT. Methods: T3 &T4 and/or positive nodal rectal cancer Patients treated for locally advanced low rectal cancer between the periods of 2017 – 2019 at our district general hospital were studied. Results: A total of 30 patients met the criteria. The median age was 67 years (11 females and 19 males). All patients had neoadjuvant chemotherapy & surgery. 2 patients had complete clinical response on MRI post neoadjuvant chemotherapy. When the histological sample was analysed, we found cure in the same 2 patients (8.7%), down stage in 12(52%) and no effect in 9(39.1). These 2 patients who had cure before surgery had pathological complete response (pCR) post op. MRI (performed about 42 days post neoadjuvant chemotherapy) showed a concordance with histology of 12(70%). Conclusion: MRI done as close to surgery as possible and about 6 to 8 weeks post NACRT could potentially pick those cancers showing complete response and would have obviated the need for surgery in 2 of the patients. MRI pre-op showed good concordance with pathology report post op and so can be relied upon for follow up with no surgery done.

Biography :

Onyekachi Ekowo is affiliated to Darent Valley Hospital, United Kingdom. He is a recipient of many awards and grants for his valuable contributions and discoveries in major area of subject research. His international experience includes various programs, contributions and participation in different countries for diverse fields of study. His research interests reflect in his wide range of publications in various national and international journals.