Journal of Nanomedicine & Nanotechnology

Monocyte-mediated delivery systems for theranostic applications in inflammatoryassociated disorders

2^nd International Conference and Exhibition on Pharmaceutical Nanotechnology & Nanomedicine

March 20 - 21, 2019 | New York, USA

Gershon Golomb

Institute for Drug Research, The Hebrew University of Jerusalem,Israel

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

The mononuclear phagocytic system (MPS) is a part of the immune system that consists of phagocytic cells, primarily monocytes, and macrophages. Both circulating monocytes and neutrophils phagocyte debris, and foreign particles in the blood including particulate drug delivery systems. Inflammation characterizes several pathological disorders including cardiovascular disorders and cancer, and the inflammatory cascade involves significant infiltration of phagocytic cells. The propensity of monocytes for rapid phagocytosis of particulate matter provides a rational approach for delivering drugs in inflammatory-associated disorders. In this presentation, we will review therapeutic as well as diagnostic approaches mediated via specially designed nanoparticles (NPs), which are avidly internalized by circulating monocytes. Monocytes can serve as a courier of specific NPs to the CNS, bypassing the bloodbrain barrier (BBB), effectively transporting drugs that are brain- impermeable. Liposomal delivery of quantum dots (QDs) enables an efficient fluorescent signal with no toxicity, in animal models of cardiovascular and cancer disorders. In addition, we will present recent results, unpublished, on the accumulation and retention of QDs in a mammary carcinoma model, following systemic administration, in comparison to passive delivery by the enhanced permeability and retention effect (EPR). The developed NPs delivery systems represent a novel approach for effective theranostic of inflammatoryassociated disorders including cardiovascular, brain, and cancer diseases.

Biography :

Gershon Golomb is a Full Professor of Pharmaceutics at the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem. His works for many years has focused on drug delivery systems. His studies have developed controlledrelease implantable and injectable drug/ gene delivery systems; from hypothesis to in-vivo studies. He is an expert in targeted nanoparticles (polymeric-based and liposomes) for the treatment of cancer, cardiovascular disorders, and inflammatoryassociated pathologies.

E-mail: gershong@ekmd.huji.ac.il