Journal of Pharmacovigilance

Microwave assisted synthesis and evaluation of polyvinyl alcohol-co-2-acrylamide-2-methyl 1 propanesulfonic acid hydrogel for oral delivery of captopril

11^th International Conference and Exhibition on Pharmacovigilance & Drug Safety

June 21-22, 2018 | London, UK

Furqan Muhammad Iqbal and Mahmood Ahmad

Bahauddin Zakariya University, Pakistan
The Islamia University of Bahawalpur, Pakistan

Scientific Tracks Abstracts: J Pharmacovigil

Abstract:

We report a highly swellable copolymeric hydrogel prepared by crosslinking poly- vinyl alcohol (PVA) with 2-acrylamido- 2-methyl-1-propanesulfonic acid (AMPS) by microwave radiation using N, Nâ??-methylenebisacrylamide (MBA) as crosslinker and very low quantities of potassium persulfate (KPS) as initiator. The prepared hydrogels were loaded with captopril and subjected to in-vitro and in-vivo evaluation. The swelling studies were performed at pH 2 and pH 7.4 to determine water absorption at lower and higher pH. The hydrogel formulations with higher proportions of AMPS and appropriate dose of radiation demonstrated maximum swelling. The prepared PVA-co-poly (AMPS) hydrogels were evaluated by FT-IR, SEM, XRD, and thermal analysis (DSC and TGA). The crosslinking in components was confirmed by FT-IR, XRD, TGA and DSC analysis. The in-vitro drug release was measured at wavelength of 205 nm using UV spectrophotometer. Drug release observed was higher at pH 2 than at pH 7.4, due to relatively more swelling capacity at lower pH in Aqueous medium. Pharmacokinetic parameters determined by oral administration to rabbits presented increased AUC, AUMC, MRT, t1/2(el), Vss and HVD for hydrogel formulations as compared to control. We can conclude that polyvinyl alcohol and AMPS polymeric network was developed successfully under the influence of microwave radiations as a controlled release drug delivery system for captopril. Recent Publications: 1. Formulation Development and Evaluation of Diphenhydramine Nasal Nano-Emulgel Hina Javed, Syed Nisar Hussain Shah & Furqan Muhammad Iqbal AAPS PharmSciTech DOI 10.1208/s12249-018-0985-4 Published online: March 22, 2018. 2. Microwave Radiation Induced Synthesis of Hydroxypropyl Methylcellulose-graft-(Polyvinylalcohal-co-AcrylicAcid) Polymeric Network and its In Vitro Evaluation. FURQAN MUHAMMAD IQBAL*, MAHMOOD AHMAD and UME RUQIA TULAIN Acta Poloniae Pharmaceutica - Drug Research 74(2), 527-541 (2017) 3. Determination of Captopril in Plasma by High-Performance Liquid Chromatography: Application in an In-Vivo Evaluation of Drug Release from Hydrogel Furqan M. IQBAL, Mahmood AHMAD, Malik M. ZUBAIR, Ume R. TULAIN & Aysha RASHID Latin American Journal of Pharmacy 34(5), 875-84/ (2015). 4. Synthesis and in vitro characterization of hydroxypropyl methylcellulose- graft-poly(acrylic acid/2-acrylamido- 2-methyl-1-propanesulfonic acid) polymeric network for controlled release of captopril Furqan Muhammad I, Mahmood A, AyshaR Acta Poloniae Pharmaceutica - Drug Research 73(1), 183-196/ 5. Lipid particulate drug delivery systems: a review Hira Ijazm, Junaid Qureshi, Ume Ruqia Tulain, Furqan Iqbal, Zeeshan Danish, Ayesha Sethi Bioinspired, Biomimetic and Nanobiomaterials Published Online: January 18, 2018, 6. Interdependent and indepedent multidimensional role of tumor microenvoirnment on hepatocellular carcinoma. Xue Wang, Waseem Hassan, Qaiser Jabeen, Ghulam Jilany Khan, Furqan Iqbal. Cytokine Published online: October 10, 2017 7. Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles. Abida Kalsoom Khan, Ain Us Saba1, Shumyla Nawazish, Fahad Akhtar, Rehana Rashid1,Sadullah Mir1, Bushra Nasir4, Furqan Iqbal, Samina Afzal, Fahad Pervaiz, Ghulam Murtaza. Oxidative Medicine and Cellular Longevity 2017, pg 1-13. 8. Rutinâ??Nickel Complex: Synthesis, Characterization, Antioxidant, DNA Binding, and DNA Cleavage Activities. Aun Raza & Shumaila Bano & Xiuquan Xu & Rong Xian Zhang & Haider Khalid & Furqan Muhammad Iqbal & Changkun Xia & Jian Tang & Zhen Ouyang Biol Trace Elem Res Published online: December 17,2016 9. Fabrication of pH-Responsive Hydrogel and Its In Vitro and In Vivo Evaluation. UME RUQIA TULAIN, MAHMOOD AHMAD, AYESHA RASHID, MUHAMMAD ZUBAIR MALIK, FURQAN MUHAMMAD IQBAL Advances in Polymer Technology 00(0), 1-14/ (2016) 10. Formulation, Evaluation and release rate characteristics of medicated jelly of vitamin C Khalid A Ibrahim, Asma Nawaz, Shamim Mumtaz, Furqan Muhammad Iqbal, Ahmad Khan*, Shahiq uz Zaman, Nasser M Abd El-Salam, Naseem Ullah, Tajamul Husain and Syed Nisar Hussain Shah Pak. J. Pharm. Sci., 30(2), (579-583).

Biography :

Furqan Muhammad Iqbal, is working as Assistant Professor of Pharmaceutics in Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan. He started his carrier in product development and quality control in Pharmaceutical Industry (Pharmacia). Up till now, he has more than 10 year experience in teaching Industrial Pharmacy and conducting pharmaceutical research. He has his expertise in Pharmaceutical Technology regarding drug delivery systems, stimuli responsive polymeric drug carriers and their evaluation. Presently, he is working on Research projects on nanotechnology and drug targeting. He has a keen interest and passion in improving the health by minimizing the adverse effects of new as well as already existing therapeutic agents.