Journal of Allergy & Therapy

Metabolic syndrome is associated with increased oxo-nitrative stress and asthma like changes in lungs

7^th International Conference on Allergy, Asthma and Clinical Immunology

September 14-15, 2016 Amsterdam, Netherlands

Vijay Pal Singh

CSIR-Institute of Genomics and Integrative Biology, India

Posters & Accepted Abstracts: J Allergy Ther

Abstract:

Studies stating obesity related risk of asthma reports significant increase in the number of people all around the globe. In view of this, mice model of obesity were found to develop airway-hyperresponsiveness (AHR) but the connecting link for role of obesity or adipogenic diet and asthma remained unclear. Previous research studies have shown the altered L-arginine and nitric oxide (NO) metabolism that stand out to be the common ground for asthma and metabolic syndrome as it also does not depends on the Body Mass Index (BMI). Such metabolic changes not only increase the asthma risk but also pose a significant threat to global health. Research also shows the consequences of high-sugar diet as an inducer for MetS without causing obesity affecting arginine/NO metabolism and airway function. Our group investigated 18 weeks long mice model using C57Bl/6J mice on normal, high fat and high fructose diet on mice model of MetS which showed us the dysfunctional arginine/NO metabolism and also some features of asthma. The result signifies high-fat-diet group developed obesity or adiposity as compared to high fructose diet group. Changes in the levels of risk factors like hyperinsulinemia, hyperglycemia and hyperlipidemia were found positive in both study groups. Hypertension in high fructose group was also seen. Asthma like changes were found after 18 weeks using airway hyperresponsiveness (AHR) as a measure and seen in both obese and non-obese mice groups. In summary, NO reduction and less arginine availability in lungs supported with oxo-nitrative stress indicated the link between obesity and asthma.

Biography :

Email: vp.singh@igib.res.in