Pharmaceutica Analytica Acta

Marine Phospholipids Based Potential Brain Drugs

2^nd International Conference on Pharmaceutics & Novel Drug Delivery Systems

20-22 February 2012 San Francisco Airport Marriott Waterfront, USA

Su Chen

Scientific Tracks Abstracts: Pharm Anal Acta

Abstract:

This presentation reviews the study of chemistry, biochemistry and pharmacolog of marine phospholipids based potential brain drugs for the prevention and treatment of neurodegenerative diseases such as Alzheimer�s disease. They include: (1) docosahexaenoyl (DHA) phospholipidome of marine biomass by mass spectrometry; (2) metabolic profiles of 1-acyl-2-DHA phospholipids and how the lipids can pass across the blood-brain barrier under the assistance of endothelial lipase; (3) 1-acyl-2-DHA aminophospholipids promote neurotrophic-cholinergic function in aged neurons; and (4) advantages of marine phospholipids based DHA brain donors for the provention and treatment of Alzheimer�s disease. Finally, the novel groups of phospholipids including DHA ether species and 1-DHA-2-acyl-phospholipids and further investigation of the lipids as new drugs are introduced.

Biography :

Su Chen (CEO at the Chainon Neurotrophin Biotechnolohy Inc, Texas USA since 2006) got his Ph..D. in Mario Negri Institute for Pharmacological Research in Milan of Italy in 1989, and was a post doctoral fellow in Italian National Research Council at Padova from 1990 - 1992. After his research position as Senior Research Fellow at Department of Chemistry of the University of Warwick in Uk from 1992-1997, he was appointed as a Faculty member in Department of Pharmacology at Rush University School of Medicine (1998-2002), and then Quest Diagnostic Nichols Institute as depatmental associate scientific director (2002-2005) in the US. He contributed significantly in areas of chemistry, biochemistry and pharmacology of marine phospholipids, particularly development of DHA - containing phospholipids for prevention and treatment of neurodegenerative disorders. He already published more than 40 articles and 3 book chapters in the fields of chemistry, biochemistry and biotechnology of lipids/bioactive lipid molecules. Su Chen now is the Secretary-General of the International Society of Dietary Supplement and Phytotherapy from 2011 - 2014.