Journal of Food Processing & Technology

Isolation of active compound from medicinal plant and evaluation of its antidiabetic activity in stz induced diabetic rats

International Conference and Exhibition on Food Processing & Technology

November 22-24, 2012 Hyderabad International Convention Centre, India

Jeba Samuel

Posters: J Food Process Technol

Abstract:

The aim of the study was to assess the antidiabetic activity of the active compound isolated from hexane extract of medicinal plant from Costaceae family against streptozotocin induced diabetic albino rats. The active compounds were characterized using gas chromatography, nuclear magnetic resonance and fourier transform infrared spectroscopy. The active compounds of medicinal plant at a dose of 5, 10 mg/kg were orally administered as a single dose per day to diabetes induced rats for a period of 30 days. The results showed that fasting blood glucose level was significantly (p<0.05) decreased compared to that of diabetic control. The dosage of 10 mg/kg is more effective than that of 5 mg/kg. Histopathological observations revealed that it is nontoxic and regenerates the toxic effect of streptozotocin. Our investigation thus showed that active compound from hexane extract of medicinal plant from Costaceae family has potent antidiabetic effect in streptozotocin induced diabetic rats and this effect was much comparable to that of the standard reference drug glibenclamide.