Brain Disorders & Therapy

Ischemia/reperfusion brain injury: return blood supply as a result of ischemia associated with stroke

7^th International Conference on Neurological Disorders & Stroke

September 20-21, 2018 | Rome, Italy

Luca Soraci

University of Messina, Italy

Posters & Accepted Abstracts: Brain Disord Ther

Abstract:

Ischemia/reperfusion brain injury refers to brain damage which occurs when blood supply returns after a period of ischemia associated with stroke. Despite this injury is caused by multiple factors, recent studies suggest an important role for the innate immune system in initiating the inflammatory cascade leading to detrimental changes. The Toll-like receptors (TLRs) play an important role in innate immunity, being capable of recognizing both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and have been recently implicated in a range of inflammatory and neurodegenerative disorders. The current knowledge linking TLRs to brain injury caused by stroke events could help obtain outline potential beneficial effects of therapeutic manipulation of TLRs. Since TLR2 and TLR4 stimulation appears to be related to inflammatory cascade mainly responsible for the damage stroke-induced, the use of TLR2 and TLR4 antagonistic molecules able to inhibit inflammatory response, could be considered. Recent Publications 1. V Sofo et al. (2017) Stroke and the Immune System: Therapeutic Targeting of Toll-Like Receptors. Ch. III ??? New Concepts in Stroke Diagnosis and Therapy. ISBN: 9781681084213. 2. Gambuzza M E et al. (2016) A new era for immunotherapeutic approaches in multiple sclerosis treatment. J. Clinic. Trials. 6(1):1-3. 3. Gambuzza M E et al. (2015) A TLR3 agonist as promising candidate in multiple sclerosis management. J. Clin. Cell Immunol. 6:339. 4. Gambuzza M E et al. (2015) The role of toll-like receptors in chronic fatigue syndrome/myalgic encephalomyelitis: a new promising therapeutic approach? CNS Neurol. Disord. Drug Targets. 14(7):903-914. 5. Gambuzza M E et al. (2014) Toll-like receptors in Alzheimer???s disease: a therapeutic perspective CNS Neurol. Disord. Drug Targets. 13(9):1542-1558.

Biography :

Luca Soraci pursued his degree in Medicine cum Laude from University of Messina in 2015. He also did his specialization in Geriatric at University of Messina in 2016. Luca Soraci is working in Department of Environmental Protection, School of Medicine, University of Messina, Italy. Having research interest in Research interest in Multiple sclerosis; innate immunity; Toll-like receptors; Toll-like receptor 3-agonist; Interferon-beta

E-mail: drlucasoraci89@gmail.com