Oral Health and Dental Management

Interleukin-10 gene polymorphisms in recurrent aphthous stomatitis

17^th International Conference on Oral & Maxillofacial Pathology

September 24-25, 2018 | Montreal, Canada

Isaac Firooze Moqadam

Tehran University Of Medical Sciences, Iran

Posters & Accepted Abstracts: Oral Health Dent Manag

Abstract:

Recurrent aphthous stomatitis (RAS) is a common oral inflammatory disease with unknown etiology in which the immune system seems to have a role in oral tolerance. Interleukin (IL)-10 is a cytokine synthesis inhibitory factor. Single nucleotide polymorphisms (SNPs) of IL10 gene could alter this cytokine production. The aim of this study was to investigate the frequencies of IL10 alleles and genotypes in a group of individuals with RAS. Genomic DNA of 60 Iranian patients with RAS was typed for IL10 gene (C/A -1082, C/T -819, and C/A -592), using the PCR-SSP method. The frequency of each allele and genotype was compared to the control group. Significantly higher frequencies of the T allele at position -819 (p=0.006) and the A allele at the position of -592 (p<0.001) were found in the patients with RAS group when compared to the controls. IL10 GA genotype at position -1082 (p=0.007), CA genotype at position -592 (p=0.001), and CT genotype at position -819 (p=0.001) were significantly higher in the RAS patients. The results of this study suggest that certain SNPs of the IL10 gene have an association with a predisposition of individuals to RAS. However, further multicenter studies should be conducted to confirm the results of this study.

Biography :

Isaac Firooze Moqadam is a Board Certificated Periodontitis. He has several publications about oral pathology, oral lesions and periodontics.

E-mail: ifirooz@gmail.com