Journal of Stem Cell Research & Therapy

Interaction of carbon nanotubes with innate immune molecular and cellular components and its translational implications

3^rd International Conference and Exhibition on Cell & Gene Therapy

October 27-29, 2014 Embassy Suites Las Vegas, USA

Uday Kishore

Accepted Abstracts: J Stem Cell Res Ther

Abstract:

Carbon nanotubes (CNTs) are quite attractive as drug delivery vehicles for targeted organ, tissue and systemic therapy. However, how these drug-laden CNTs interact with components of the immune system can have profound effect on the intended outcome of the drug delivery. For instance, the nature of interaction between CNTs and immune cells, such as phagocytes, can lead to rapid elimination of the nanoparticles from the systemic circulation, and thus, interfere with specific delivery. Furthermore, engagement of phagocytic cells with CNTs can activate a string of innate immune pathways, precipitating in an inflammatory response and modulation of adaptive immune system. Therefore, understanding the interactions between nanoparticles and immune system is essential for their strategic and specific use for in vivo delivery. Since innate immune system offers the first line of defense and clearance mechanism against non-self and altered self, we have shown via a string of studies that the complement system sees the molecular pattern on pristine and derivatised CNTs. CNTs that activate the complement are phagocytosed more efficiently and induce an anti-inflammatory response as compared to non-complement activating CNTs. Thus, pattern recognition and complement deposition can determine the fate of CNT-mediated drug delivery. This concept is now being exploited, using recombinant forms of soluble innate immune humoral factors immobilized on various CNTs, to target glioblastoma, graft rejection and allergy.

Biography :

Uday Kishore, a Cellular and Molecular Immunologist, is the Director of the Centre for Infection, Immunity and Disease Mechanisms, Brunel University, London. He researches on the role of innate immunity in a range of disease processes and therapeutic interventions. He earned his MSc and PhD from University of Delhi, India. He has previously been a NASA Fellow at Salk Institute, USA, MRC Fellow at Oxford, and Humboldt Fellow in Germany. He has authored over 100 research papers, 20 book chapters, 2 patents and edited 3 books. He is also the recipient of MRC Inventor?s prize, European Commission Young Scientist prize, and, more recently, Mother Teresa Excellence Award 2014.