Journal of Psychiatry

Increased IL-17 and TGF-? as a positive correlation of pro-inflammatory response with major depressive disorder

Euro Global Summit and Medicare Expo on Psychiatry

July 20-22, 2015 Barcelona, Spain

Mohammad Hasan Davami1, Rasoul Baharlou1 and Ahmad Ghanizadeh2

Posters-Accepted Abstracts: J Psychiatry

Abstract:

Introduction: Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum levels of IL-21, IL-17, and transforming growth factor ? (TGF-?) between patients with major depressive disorder and health controls. Material and Methods: A convenient sample of 41 patients with major depressive disorder and 40 healthy age-matched controls were participants of this study. The patients were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum level of the interleukins of IL-21, IL-17, and TGF-? were assessed using ELISA-kits. Results: The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum level in the patients and the control group was 10.03±0.6 and 7.6±0.6 pg/ml, respectively (P=0.01). TGF-? level in the patients group was significantly higher than that of the control group; 336.7±20.19 vs. 174.8±27.20 pg/ml, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/ml (P>0.05). Conclusion: Considering pro-inflammatory cytokines, current results support the association of inflammation and depressive disorder. So, it seems that pro-inflammatory factor profile can be used as indicator in following of depression progress and its treatment impacts.