Pharmaceutica Analytica Acta

In vitro evaluation of intimate gels: Application of nine marketed formulations

18^th Annual Pharmaceutical and Chemical Analysis Congress

November 05-06, 2018 | Madrid, Spain

S Bennis, M Alami Chentoufi, A Cheikh, H Miftah, M Oulad Bouyahya Idrissi, M Draoui and M Bouatia

Mohammed V University, Morocco
Abulcasis University, Morocco
Pediatric Hospital, Morocco

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Background: The intimate area is a delicate ecosystem characterised by an acid pH. The use of intimate gel helps balance vaginal pH level, which in turn helps in preventing itchiness and bacterial infection. Given the multitude of intimate gels on the market, it would be interesting to have quantitative techniques to evaluate the pH of these products. Purpose: To evaluate the behavior of intimate gels in the presence of an increasing amount of acidity in vitro and to demonstrate their physiological behavior. Material & Methods: We studied in vitro the behaviour of nine intimate gels. For this, 5 ml of the gel was diluted in 10 ml of distilled water, to which were added increasing amounts of 0.1 N HCl in increments of 0.1 ml every 30 s up to a total acid volume of 4 ml. The variation of pH in the mixture was followed by pH-metry. Each test was repeated three times. Results: The in vitro behaviour of nine intimate gels in the presence of increasing amounts of 0.1 N HCl is represented in figure 1. Conclusion: According to the results, the pH of the gels 7, 8, 3, 4, 5, stabilizes around 3 which are compatible with the pH of the vaginal flora. They can be prescribed for daily use when no disorder is present. Regarding gels 1, 2 and 6 which have a slightly alkaline pH (pH between 7 and 8), they can be prescribed in case of thrush. The gel 9 which pH is alkaline and stabilizes at pH 6 may be prescribed for vaginal mycosis caused by candida.

Biography :

E-mail: soukainabennis90@gmail.com