Pharmaceutica Analytica Acta

In vitro dissolution pattern of Metronidazole (400 mg) tablet in the presence of different fluids

International Conference on Bio-Pharmaceuticals, Biosimilars & Pharma Industry

February 28 - March 01, 2019 Osaka, Japan

Kiran Bikram Bohara

Tribhuwan University, Nepal

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Metronidazole occurs as pale yellow crystals that is slightly soluble in water and alcohol. Our study had focused on the in vitro dissolution study of Metronidazole in the presence of different fluids (ORS solution, rice water, lentil soup, watermelon juice, apple juice, mango juice and pomegranate juice, and black and green tea.) which have been commonly using in diarrhoeal conditions. Dissolution study was performed as per mentioned in Indian pharmacopoeia. For the analysis of study we used graphpad prism version-8 and Microsoft excel. ANOVA followed by Dunnett’s test was performed for the comparison of percentage drug release in different fluids. Different dissolution medium were prepared from 200 ml of fluids and 700 ml of 0.1 N HCl. In lentil soup (mung bean) dissolution of Metronidazole tablet (78.69±1.89) doesn’t compiled with IP specification which is significantly decreased when compared with average mean percentage drug release on standard dissolution medium (0.1 N HCl). When compared with standard dissolution medium there is significantly decrease in percentage drug release in rice water, watermelon, mango, pomegranate juice, black and green tea but values were within the specifications.

Biography :

E-mail: kiranbikram029@gmail.com