Journal of Nanomedicine & Nanotechnology

In vitro controlled release of 5-FU drug from a stimuli-responsive microgel/liposome biomaterials at different temperatures

11^th International Conference and Expo on Nanoscience and Molecular Nanotechnology

October 20-22, 2016 Rome, Italy

Damla Ulker, Inci Barut, Erol Sener and Vural Butun

Eskisehir Osmangazi University, Turkey
Anadolu University, Turkey

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

Poly (ethylene glycol) stabilized stimuli-response microgels have been used as a drug carrier and a release system due to its low toxicity and high biocompatibility nature. They are promising material for the advancement of specific drugs carriers like cancer drugs. They have huge pore size which can be decreased by varying cross-linker ratio. They might be modified with liposome and magnetic nanoparticles as well. Liposome/microgel stimuli-response drug release system may provide better application opportunities such as delivery of multiple components and imaging agents, diagnostic and therapies. In this study, multi-response liposome/microgel hybrid drug delivery and targeting system was synthesized. 5-fluorouracil (5-FU) drug was loaded into liposomes in aqueous media, and then a water soluble monomer based multi-responsive microgel hosting liposome-5-FU system was synthesized. Finally, 5-FU loaded hybrid system was covered with magnetic Fe3O4 nanoparticles in order to provide a response to magnetic field. This hybrid system was used in vitro studies as a drug carrier for a target and controlled drug release system in phosphate buffer solution (pH 7.4) incubated at 37°C and 42°C and physiological saline solution incubated at 37°C. All microgel, liposome and liposome/microgel systems were characterized by using dynamic light scattering, zetapotentiometer, transmission electron microscopy. Magnetic Fe3O4 nanoparticles covered liposome/microgel hybrid system was characterized by using TEM. The release of 5-FU from liposomemicrogel hybrid system was analyzed using high-performance liquid chromatography with ultraviolet spectrophotometer detector at 266 nm.
Acknowledgement: ESOGU and the Scientific and Technological Research Council of Turkey (TUBITAK) are thanked for financial supports (GN: 201619C104 and 115Z726, respectively)

Biography :

Damla Ülker is a PhD student at the Department of Polymer Science and Technology of Eskisehir Osmangazi University. She works in various projects based on polymer synthesis and their application studies. Her recent research is based on “Synthesis and Characterization of Novel Microgels, Nanometals, Nanocomposites, Block Copolymer Stabilizers for Related Application Studies”. She has great experience on nanometal dispersion preparation, ATRP chemistry and heterogeneous polymerization techniques including both emulsion and dispersion polymerizations.

Email: damlaulker@gmail.com