Journal of Nanomedicine & Nanotechnology

In silico study of nanoparticle size effect for nanomedicine

7^th International Conference on MATERIALS SCIENCE AND NANOTECHNOLOGY

December 05-06, 2022 | Dubai, UAE

Giancarlo Franzese

Universitat de Barcelona, Spain

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Nanoparticles are used in many drug delivery systems. Their properties in biological fluids are determined by proteins adsorbing on the nanoparticles, forming a protein corona. We use modeling and computer simulations combined with Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) experiments to investigate the kinetics of protein corona formation by three blood proteins (fibrinogen, transferrin, human serum albumin) onto different-sized silica nanoparticles. Our simulations predict differences in the corona composition as the size changes, allowing us to predict the protein corona kinetics at the minute timescale and how it changes in complex milieus with time. This result is particularly relevant in cases where a nanoparticle travels through different biological environments. It is critical to understand how to modulate the protein corona by size-controlling the interaction within different biomolecules. We will also present our latest results on analyzing UV Resonant Raman Spectra for protein coronas based on Machine Learning to better understand how the adsorption affects the protein and the biomolecules' ability to interact with receptors. Tuning the protein corona could be exploited to design specific nanoparticle properties, helping to better design drug-delivery carriers or generate biocomplexes for nanotheranostics.