Journal of Vaccines & Vaccination

Immuno potentiation of hepatitis B vaccine using biodegradable polymers as adjuvant

9^th Global Summit and Expo on Vaccines & Vaccination

November 30-December 02, 2015 San Francisco, USA

S M Sivakumar, Mohammed M Safhi and Aamena Jabeen

Jazan University, Kingdom of Saudi Arabia

Posters-Accepted Abstracts: J Vaccines & Vaccin

Abstract:

Vaccines are considered as the most successful medical intervention against various infectious diseases. However, there are significant obstacles for improving immune response especially recombinant vaccines. Therefore, immunopotentiators (adjuvants) are included in vaccine formulation in order to augment immune response. Since 90 years alum is the only adjuvant approved by US FDA for human use. Recently, MF 59 and ASO4 adjuvants were developed and approved for human use. Due to the poor adjuvancity, conventional hepatitis B vaccine require at least 3 dose schedule either at 0, 1 and 6 months or 2, 4 and 8 months depending on the mode of transmission. Though hepatitis B vaccination is more successful but the efficacy of vaccine to deliver a long lasting immune response become a debate because vaccine efficiency also declines with increasing age. Therefore, the development of a delivery system for the hepatitis B vaccine, that could induce the desired antibody levels from a single injection, would be of enormous benefit. In this work the efficacy of various biodegradable polymeric micro particles were screened for their compatibility as an adjuvant for hepatitis B vaccine. Among the various polymeric micro particles screened, the chitosan micro particles was found to be better adjuvant for hepatitis B vaccine, since it induced robust immune response after a single step immunization when compared to alum adsorbed hepatitis B vaccine. The development of single contact hepatitis B vaccine based on chitosan polymer is very important advancement towards the betterment of human health care.

Biography :

Email: drsmsivakumar@gmail.com