Pharmaceutica Analytica Acta

Hyphenation of dispersive liquid-liquid microextraction with chromatographic techniques for the detection of drugs of abuse

International Conference and Exhibition on Advances in HPLC & Chromatography Techniques

March 14-15, 2016 London, UK

Rajeev Jain

Directorate of Forensic Science Services, India

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Tracing of drugs of abuse at low concentration levels in various matrices of forensic, clinical and biological interest is always been a challenging task for analytical chemists. Traditional sample preparation methods such as solid phase extraction (SPE) and liquid-liquid extraction (LLE) are well known for their disadvantages of being environmentally unfriendly, costly and labor intensive. Dispersive liquid-liquid microextraction (DLLME), introduced in 2006 has gained a large attention from analytical chemists. DLLME is a fast, eco-friendly, cost-effective and easy microextraction technique offering high enrichment factors and extraction efficiencies. Since its introduction, DLLME has been hyphenated with various instrumental techniques like high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and UV-Visible spectrophotometer for the detection of drugs of abuse in various complex matrices such as blood, urine, saliva etc. The capability of coupling of DLLME with injection port derivatization (IPD) offers an attractive alternative for the analysis of polar analytes by GC-MS. This presentation is focused on the discussion of recent advances in coupling of DLLME with chromatographic techniques for the detection of drugs of abuse as well as other analytes of forensic interest in various complex matrices.

Biography :

Email: rajeevjaincfsl@gmail.com