Journal of Liver

Host factors associated with spontaneous hepatitis C virus clearance

3^rd World Congress on Hepatitis and Liver Diseases

October 10-12, 2016 Dubai, UAE

Engy Mohamed El-Ghitany

Alexandria University, Egypt

Posters & Accepted Abstracts: J Liver

Abstract:

Background: Spontaneous clearance occurs in a varying proportion of hepatitis C virus (HCV) infected individuals. The factors associated with it are debatable. Recognizing these factors may lead to better understanding of HCV natural history and eventually improve prediction and management models. Aim: This study was performed to determine the host factors associated with spontaneous HCV clearance. Methods: Among 847 HCV antibody positive individuals who denied receiving HCV antiviral treatment, 306 spontaneously cleared the virus (36%). Persistent infection and clearance groups were compared regarding host, behavioral and possible acquisition factors. Results: Neither gender nor age showed significant association but males >=45 years had significantly higher clearance rate (40.2%) compared to males <45 years (28.8%), OR=1.66; 1.07-2.57 CI. History of schistosomiasis and receiving parenteral treatment for schistosomiasis had odds ratio (1.92; 1.28-2.88 CI and 1.53; 1.13-2.08) respectively. History of incarceration was associated with low clearance rate (10.5%, OR=0.20; 0.05-0.88 CI). Frequent dentist visits was significantly associated with higher HCV clearance rate (39.9% vs. 30.1%, OR=1.55; 1.15-2.08). Conclusion: Higher probability of HCV clearance is associated with schistosomiasis co-infection, >=45 years old in males and frequent dentist visits, while low clearance rate was associated with history of incarceration. These results suggest that the mode of transmission may affect the clearance probability.

Biography :

Email: ingy.elghitany@gmail.com