Hereditary Genetics: Current Research

Heterogeneity, phenotypic and genotypic instability of the primary tumor and its metastasis

4^th International Congress on Epigenetics & Chromatin

September 03-05, 2018 | London, UK

Nawel Agher and A Tou

University Hospital Center  Hassani Abdelkader of Sidi Bel Abbes, Algeria
Djilali Liabes University, of Sidi Bel Abbes Algeria

Posters & Accepted Abstracts: Hereditary Genet Curr Res

Abstract:

The heterogeneity of cancers presents one of the major problems of therapeutic management, which can explain the fall of many cancer patients after treatment. The study of these changes at the level of the primary tumor and its metastasis and the thorough knowledge of points of difference would improve the therapeutic choice and thus increase the survival and quality of life of patients. The aim was to study primary cancer and its metastasis in all its aspects in order to find hypothetical explanations on the behavior of the moving cell. We performed a comparative study between the primary tumor and its secondary tumor in 10 cases of cancer diagnosed at the Department of Pathology, Hospital University Center, Sidi Bel Abbes, Algeria. Our work consisted in correlating clinical data with anatomo-pathological aspects including a histopathological rereading of all lesions and using immuno histochemical techniques using markers: HER2, progesterone, estrogen, P53, Ki67, cytokeratin, Kappa, Lambda, to compare between the primary tumor and its metastasis in terms of the degree of differentiation (histopathological grade); the proliferative potential and the type of proliferation adopted by the moving cell; This variability can explain the treatment failure and is often based on the histopathological and biological profile of the primary tumor is not taking consideration of the tumor cells, having had the ability to depart from the primary tumor, borrow the blood stream and proliferate in another environment than the initial environment thereby confirming their aggressive potential and that should be taken into account in the therapeutic choice. Fig 1: Primary and Secondary tumor image. Recent Publications: 1. A F Chambers, A C Groom and I C MacDonald (2002) Dissemination and growth of cancer cells in metastatic sites. Nature Reviews Cancer 2(8):563???572. 2. S A Eccles and D R Welch (2007) Metastasis: recent discoveries and novel treatment strategies. Lancet 369(9574):1742??? 1757. 3. I J Fidler (2003) The pathogenesis of cancer metastasis: the seed and soil hypothesis revisited. Nature Reviews Cancer 3(6):453???458. 4. G P Gupta and J Massague (2006) Cancer metastasis: building a framework. Cell 127(4):679???695. 5. R A Gatenby

Biography :