Journal of Stem Cell Research & Therapy

Gastrointestinal stromal tumor (GIST) of the adrenal gland responding markedly to imatinib: A rare case report

3^rd International Conference and Exhibition on Cell & Gene Therapy

October 27-29, 2014 Embassy Suites Las Vegas, USA

Haya Azouz and Ahmed Abu-Zaid

Scientific Tracks Abstracts: J Stem Cell Res Ther

Abstract:

Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the gastrointestinal (GIT). The occurrence of these neoplasms ectopically outside the GI tract is extremely uncommon. Only one case of primary adrenal GIST has been described in the literature. In this account, we report a second case of primary adrenal GIST in a 34-year-old male who presented with 5-week history of gradually progressive left flank pain and early satiety. Physical examination was notable for a moderately enlarged and tender mass involving the left flank region. All laboratory tests including complete blood count, renal, bone, hepatic, coagulation and tumor profiles were normal. Whole-body positron emission tomography (PET)/computed tomography (CT) scan showed a 14x11 cm hypermetabolic fluorodeoxyglucose (FDG)-avid mass lesion involving the left adrenal gland and dorsal part of the left hemi-diaphragm. There was no evidence of distant metastasis. In consideration of a neoplastic lesion, an ultrasound-guided core-needle biopsy revealed tumor cells that were immunoreactive to CD-117 (c-kit) and CD-34, and negative to CD-31, S-100, cytokeratin, desmin and vimentin - features characteristic of GIST. Surgical resection was advised, but patient refused. Subsequently, patient was offered imatinib (a tyrosine-kinase inhibitor). Surgical resection was advised, but patient refused. Subsequently, patient was offered imatinib (tyrosine-kinase inhibitor). Following therapy, a 3-month followup PET/CT scan showed markedly near-complete resolution of the metabolic activity of the known left adrenal mass lesion. Moreover, patient reported markedly reduced left flank symptoms. Although rare, GIST arising from adrenal gland can be confused with GIST arising from the greater curvature of stomach.

Biography :

Haya Azouz is a third year medical student at Alfaisal University in Riyadh, KSA. She has started working on several research projects since the first month of her medical life. She has also worked on amending some of the amazing masterpieces in medicine by reporting few flaws in Guyton and Hall textbook of medical physiology and Gray's Anatomy.