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Gallstones - Updates on recent developments in genetic, biochemical and metabolic mechanisms
World Congress on Pharmacology
July 20-22, 2015 Brisbane, Australia
Sing-Moo Huang
Posters-Accepted Abstracts: Clin Exp Pharmacol
Abstract:
At the beginning, the monograph describes the whole aspect of gallstone disease and at the end, sums the future promise of gallstone research, especially the genetic research of gallstones. The book clings to strict scientific principles and is designed to explore the whole aspect of gallstone diseases from the micro world of the genetic defects, basic metabolisms of bile lipids in cholesterol gallstone patients to the macro world of clinical triple defects of gallstone patients. The monograph is divided into two volumes. Volume I updates researches on epidemiology, classification, genetic defects resulting in gallstone disease and basic metabolism of gallbladder lipids. It delineates also recent breakthroughs and developments in genetic factors affecting cholesterol gallstone formation including genes ABCB11, ABCG5/G8, GPBAR1, OSTĪ±/OSTĪ², Megalin and Cubilin proteins. It also covers basic metabolisms of bile lipids (cholesterol, bile acids and phospholipids) in relation to cholesterol gallstone stone formation. It also covers some aspects of the epidemiology, classifications, chemical and crystallographic studies of gallstones. Volume II depicts motor dysfunction, etiology and pathogenesis of gallstones. It deals with motor dysfunction in calculous gallbladders as well as reactive oxygen species as a pathogenic mechanism of gallstones formation, etiology and pathogenesis of pigment, calcium carbonate and intra-hepatic gallstones are also described. In the talk, the speaker will highlight in detail the signaling pathways of GPBAR1 receptor in relation to cholesterol gallstone formation, the crystallographic studies of calcium carbonate gallstones and the role of calcium ion and bicarbonate anion play in the formation of calcium carbonate gallstones.