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Functional role of cdc and adcc for rsv-specific antibodies following maternal vaccination
4th International conference on Vaccines, Vaccination and Immunization
August 18-19, 2023 | Webinar

Damian Chukwu Odimegwu

University of Nigeria Nsukka, Nigeria

Scientific Tracks Abstracts: Journal of Vaccines & Vaccination

Abstract:

Introduction: Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract illness (LRTI) in infants and children worldwide. Currently, no safe and licensed vaccine against RSV exist. Maternal vaccination has been evaluated as a control strategy in the young. Antibody-mediated events including complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) are antibody-mediated effector mechanisms and the principal means of control in post-maternal vaccination scenario. Therefore, this study was carried out to characterize how maternal-derived RSV-antibodies in mice pups mediate CDC and ADCC as antibody-dependent protection mechanism. Methods: Sera were collected from mice pups birthed by mother mice that were vaccinated in a prime-boost fashion using codon-optimized genetic vaccine expressing the fusion protein of RSV (RSV-F). Sera were analyzed for CDC by application of complement fixation test. ADCC was analyzed via FC-gamma receptor activation test through measurement of IL-2 release in BW5147 cells. Results: Following vaccination, a 512-fold increase in RSV-neutralizing antibodies, and a 100-fold reduction in RSV copy numbers were recorded in mice pups. Serum antibodies in pups from vaccinated mothers were found to activate and fix complement leading to a 5-fold increase in antibody fixation titre. FC-gamma receptors II (CD16) and IV (CD64) of BW5147 effector cells were both activated in response to the RSV-specific antibodies leading to IL-2 release (>1.0 OD). Conclusion: The results obtained suggests the positive role of CDC and ADCC and could explain in part the mechanistic basis of the efficacy of RSV vaccine in mice pups following maternal vaccination.

Biography :

Damian is a Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka

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