Awards Nomination 20+ Million Readerbase
PMC/PubMed Indexed Articles

Maintenance and Intensification of Bivalent Oral Poliovirus Vaccine Use Prior to its Coordinated Global Cessation

MEFA (multiepitope fusion antigen)-Novel Technology for Structural Vaccinology, Proof from Computational and Empirical Immunogenicity Characterization of an Enterotoxigenic Escherichia coli (ETEC) Adhesin MEFA

View More »

Google Scholar citation report
Citations : 2051

Journal of Vaccines & Vaccination received 2051 citations as per Google Scholar report

Journal of Vaccines & Vaccination
Journal of Vaccines & Vaccination peer review process verified at publons
Flyer image
Indexed In
  • Academic Journals Database
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • China National Knowledge Infrastructure (CNKI)
  • Scimago
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
View More
Useful Links
Share This Page
Open Access Journals
View More
Functional role of cdc and adcc for rsv-specific antibodies following maternal vaccination
4th International conference on Vaccines, Vaccination and Immunization
August 18-19, 2023 | Webinar

Damian Chukwu Odimegwu

University of Nigeria Nsukka, Nigeria

Scientific Tracks Abstracts: Journal of Vaccines & Vaccination

Abstract:

Introduction: Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract illness (LRTI) in infants and children worldwide. Currently, no safe and licensed vaccine against RSV exist. Maternal vaccination has been evaluated as a control strategy in the young. Antibody-mediated events including complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) are antibody-mediated effector mechanisms and the principal means of control in post-maternal vaccination scenario. Therefore, this study was carried out to characterize how maternal-derived RSV-antibodies in mice pups mediate CDC and ADCC as antibody-dependent protection mechanism. Methods: Sera were collected from mice pups birthed by mother mice that were vaccinated in a prime-boost fashion using codon-optimized genetic vaccine expressing the fusion protein of RSV (RSV-F). Sera were analyzed for CDC by application of complement fixation test. ADCC was analyzed via FC-gamma receptor activation test through measurement of IL-2 release in BW5147 cells. Results: Following vaccination, a 512-fold increase in RSV-neutralizing antibodies, and a 100-fold reduction in RSV copy numbers were recorded in mice pups. Serum antibodies in pups from vaccinated mothers were found to activate and fix complement leading to a 5-fold increase in antibody fixation titre. FC-gamma receptors II (CD16) and IV (CD64) of BW5147 effector cells were both activated in response to the RSV-specific antibodies leading to IL-2 release (>1.0 OD). Conclusion: The results obtained suggests the positive role of CDC and ADCC and could explain in part the mechanistic basis of the efficacy of RSV vaccine in mice pups following maternal vaccination.

Biography :

Damian is a Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka

HTML