Brain Disorders & Therapy

Fractional anisotropy intervals derivatives from the diffusion tensor image in peritumoral region and the association with survival in glioblastoma: evidence using survival and correspondence analysis

7^th International Conference on Neurological Disorders & Stroke

September 20-21, 2018 | Rome, Italy

Eduardo Flores Alvarez

National Autonomous University of Mexico, Mexico

Scientific Tracks Abstracts: Brain Disord Ther

Abstract:

Introduction: The Diffusion tensor image (DTI) is leading the analysis of brain lesions, and its derived biomarker the fractional anisotropy (FA) can be related to invasion, infiltration, and extension of brain neoplasms. Aim: We aim to evaluate FA values in three tumor regions of patients with glioblastoma (GB) and its association with intervals of overall survival (OS) using survival and correspondence analyses. Methodology: A retrospective study in 36 patients with GB: 23 (63.9%) males, 46???14 y; and 13 (36.1%) females, 53???13 y. Patients were followed up for 36 months. We measured DTI-derived FA at edema, enhancing rim and necrosis. To account for the tumor location, we used a four-level MRI-based classification based on the GB involvement of the subventricular zone and cortex. Kaplan-Meier method and the Log-Rank test assessed the survival curves between four subgroups based on tumor location. Correspondence analysis evaluated the association between OS (grouped in 7 six-month intervals) and FA measurements in the tumor regions. Results: Median FA values were higher in the normal brain regions (0.351), followed by peritumoral edema (0.190), enhancing ring (0.116) and necrosis (0.071). Comparisons among FA values among tumor regions showed a significant difference, p<.001. The Kaplan???Meier estimates indicated that the median OS for all patients was 19.3 months; the Log-Rank test to compare differences in the OS curves among subgroups was significant ??2 (3)=8.48, p=0.037. Correspondence analysis showed that a positive association between FA values in the edema region and the survival intervals was significant ??2 (18)=30.996, p=0.029. Conclusions: The alternative multivariate assessment of correspondence analysis might supplement the traditional survival analysis in patients with GB. A close follow-up of the variability of FA in the peritumoral edema region is predictive of the OS within specific six-month interval subgroup. Further studies should focus on a predictive model combining surgical and DTI biomarkers.

Biography :

Eduardo Flores Alvarez pursued his Master´s Degree from National Autonomous University of Mexico (UNAM) School of Medicine, Mexico with focus on the application of advanced magnetic resonance in glioblastomas. He completed his neurosurgical training program from General Hospital of Mexico of the UNAM and is the Head of Endoscopic NeuroSurgery Department. His area of research include: the advanced analysis of magnetic resonance.

E-mail: vladfu24@gmail.com