Journal of Nanomedicine & Nanotechnology

Formulation and evaluation of tamoxifen citrate-loaded silk fibroin nanoparticulate drug delivery system

14^th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology

April 09-11, 2018 Amsterdam, Netherlands

Gangadharappa H V and Shahid Ud Din Wani

Jagadguru Sri Shivarathreeshwara University, India

Posters & Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Silk fibroin (SF) is derived from Bombyx mori and is a protein proven to be of magnificent bio-compatibility and in-vivo biodegradability. It is important to formulate and design the nanoparticles which are nontoxic and safe for the future clinical application. The aim of the present work was to develop tamoxifen citrate (TC) loaded silk fibroin (SF) based nanoparticles by aqueous solution method. The prepared nanoparticles were evaluated for its zeta potential, surface morphology, drug content, encapsulation efficiency and in-vitro drug release. The prepared nanoparticles were characterized by FTIR and X-ray diffraction. The diameters of the obtained nanoparticles were in the range of 210-250nm, drug entrapment of 56 to 79%, loading content was found to be within 22 to 43% respectively and zeta potential of -11.6 to -15.4mV. The XRD spectrum suggests that the characterized diffraction peaks of β-sheets of SF with both lower and broader peak within 20-23º confirming that TC was encapsulated in nanoparticles in amorphous form. In-vitro drug release from the prepared nanoparticles was found to be 41±1.2 to 55±1.5%. Finally, from the results it was concluded that silk fibroin-based nanoparticle drug delivery system could serve as a promising carrier system for better delivery of the drugs. hvgangadharappa@jssuni.edu.in