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Journal of Bioequivalence & Bioavailability
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Formulation and evaluation of liquid crystalline nanoparticles of artemether and lumefantrine for the treatment of malaria
Joint Event: 3rd International Conference on Biopharmaceutics and Biologic Drugs & 5th International Pharmacy Conference
August 31-September 01, 2017 Philadelphia, USA

Vandana Chaudhary, Shakir Hussain and Vijay Bhalla

SGT College of Pharmacy, India
Sidhi Vinayak College of Science, India

Posters & Accepted Abstracts: J Bioequiv Availab

Abstract:

Liquid crystalline nanoparticles of artemether and lumefantrine were prepared by using glyceryl monooleate, oleic acid, poloxamer 407, ethanol and water. The optimization of liquid crystalline nanoparticles was achieved by response surface methodology (BBD. 17 trials were prepared making use of artemether, lumefantrine and oleic acid in varying concentration and GMO, poloxamer, ethanol and water were kept constant. Out of these F9 formulation was found best formulation. The selection was made based on particle size and entrapment efficiency of artemether and lumefantrine. Optimized formulation (OF1) contained particle size in the range of 193.5-194 nm (PDI 0.10) indicated that particle size was uniform. Entrapment efficiency of artemether and lumefantrine were found 85% and 95.5%. Release study of artemether and lumefantrine revealed that the drugs were released in a remarkably controlled manner up to 72 hrs. Physical and chemical stability study revealed that the optimized formulation (OF9) was physically and chemically stable.

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