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Formulation & characterization of nicorandil and budesonide loaded drug delivery using Diffucap technology
8th Indo Global summit and Expo on Vaccines, Therapeutics & Healthcare
November 02-04, 2015 HICC, Hyderabad, India
Sowjanya Battu, Y Prasanna Raju, Subba Reddy and V Uma Maheswara Rao
CMR College of Pharmacy, India
Scientific Tracks Abstracts: J Vaccines Vaccin
Abstract:
Multiparticulate systems are specifically suitable for achieving controlled or delayed release oral formulations with smallest amount of risk of dose dumping, flexibility of combination to achieve different release patterns, less gastric residence time (pellets, granules, microparticles, nanoparticles, etc.). Pelletization is referred to as an agglomeration process, that converts fine powders or granules of bulk drugs into small, free flowing, spherical or semispherical units called as pellets. Aim of the current study was to formulate, evaluate and perform in vitro drug release studies of multiparticulate-pulsatile-controlled drug delivery of Nicorandil and Budesonide using Diffucap technology with Ethyl Cellulose 7, 10, 20 Cps as CR polymers and Eudragit S 100, PL 100 as time controlled polymers. Drugā??polymer compatibility studies were performed by using FTIR, surface morphology for the pellets was studied by SEM analysis. The in vitro drug release studies were performed using USP dissolution test apparatus type I and the results were used to optimize the best combination of controlled release and pulsatile release polymers to get desired lag time of 6 hrs and drug release for about 12 hrs.