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Flourinated branched glycopolymer gold nanoclusters for cancer theranostics
33rd World Nano Conference
October 24-25, 2022 | WEBINAR
Priyanka Sharma and Asifkhan Shanavas
Institute of Nano Science and Technology, India
Posters & Accepted Abstracts: J Nanomed Nanotechnol
Abstract:
Gold nanoclusters have been extensively explored as diagnostic agents in cancer and drug delivery because of their fluorescent properties. However, there are few critical issues like stability, reproducibility, long term health effects and cellular & immune response which needs to be addressed for getting site specific delivery along with high sensitivity. Here we have designed self-reducing branched fluorinated glycopolymer gold nanoclusters as diagnostic agents for cancer. These clusters have the ability to self-reduce themselves and get stabilized without adding any external reagents imparting reproducibility and stability without any toxicity to the normal cells. Along with fluorescent property these clusters possess fluorine moiety which imparts 19F magnetic resonance imaging at the same time making them dual modality imaging agents. These clusters were preclinically tested for acute toxicity and acute inflammation studies and no adverse effects were found.