Clinics in Mother and Child Health

Fifty three newborns with hypoxic-ischemic encephalopathy treated with hypothermia therapy using the neonatal laminar flow unit

28^th World Congress on Neonatology & Diagnosis

December 06-07, 2018 | Amsterdam, Netherlands

Jose M R Perez

Maternidade Sao Miguel, Casa de Saude de Guarulhos, Brazil
Stella Maris Hospital, Brazil

Posters & Accepted Abstracts: Clinics Mother Child Health

Abstract:

Aim: The aim of this trial was to do clinical observations of newborns diagnosed with hypoxic ischemic encephalopathy and treated with hypothermia therapy with the neonatal laminar flow unit. Materials & Methods: The trial included 53 newborns, delivered in the same hospital as they received the treatment, under 35 weeks of gestation and with up to six hours of life. Total body cooling was achieved using the neonatal laminar flow unit for 72 hours, with continuous rectal temperature servo control, isolation and humidification. Outcome measures were cerebral palsy, a Bayley II Mental Development Index score<70, hearing loss or blindness. We have compared findings with previously published studies. Results: We included 53 newborn infants (73% male) with a birthweight of 3.562±1548 gm and gestational age of 38±3.4 weeks. To classify the severity of hypoxic-ischemic encephalopathy, we used the Siben Neurologic Score and the Sarnat grading scale. The majority of newborns (73%) were diagnosed with severe HIE, after assessment of the Siben Neurologic Score, and the remaining newborns (27%) were diagnosed with moderate HIE, following the same assessment. Each of those diagnostics was confirmed after assessment of the Sarnat staging. Total body cooling (33-34°C) was achieved in 75 minutes and maintained with servo control. The mortality was 28.3% (15 newborns), at 18-24 months of age, five of the 38 survivors were diagnosed with cerebral palsy (9.4%), two were diagnosed with blindness (3.7%), and one with impaired hearing (1.8%). Conclusion: Because, these results were in the same range as those reported by other studies, we conclude that the use of the neonatal laminar flow unit to supply total body hypothermia therapy in newborns with HIE was effective.

Biography :

E-mail: joseperezneo@gmail.com