Journal of Nanomedicine & Nanotechnology

Febuxostat self-nano emulsifying drug delivery system with enhanced dissolution characters

Joint Event on 23^rd International Conference on Nanomaterials science & Nanoengineering & Technology & International Conference and Exhibition on Pharmaceutical Nanotechnology and Nanomedicine

April 18-19, 2018 | Las Vegas, USA

Usama A Fahmy

King Abdulaziz University, Saudi Arabia

Accepted Abstracts: J Nanomed Nanotechnol

Abstract:

Utilization of lipid-based drug delivery systems has recently gained focus for drugs characterized by poor aqueous solubility. The improved aqueous solubility overcomes one of the main barriers that limit their bioavailability (49%), moderate bioavailability as a result of its poor solubility. The objective of this work was to improve the solubility and oral bioavailability of Febuxostat (FBX), FBX was formulated as self-nano emulsifying drug delivery system (SNEDDS) utilizing various oils, surfactants, and surfactants. The solubility of FBX in various oils, surfactants, and co-surfactants was determined; nine formulae were formulated to determine the smallest globular size, in vitro drug release and drug-excipient interaction. Results revealed that stable FBX-SNEDDS were successfully developed. SNEDDS composed of castor oil, Tween20, and propylene glycol 200 successfully improved solubilization of FBX. The cumulative release is not showing a big difference between the control and the formula at the first 20 minutes. But thereâ??s a significant increase different between the cumulative releases of the control at 60 minutes, FTIR analysis did not show any drugexcipient interaction. usamafahmy@hotmail.com