Journal of Food Processing & Technology

Extraction of crystalline nanocellulose from banana pseudostem and its utilization in developing drug loaded bio-nanocomposite film

3^rd World Congress on Advances in Food Science, Processing and Technology

May 13-14, 2019 Tokyo, Japan

Pratiksha Shrestha

Department of Food Technology and Quality Control, Nepal

Scientific Tracks Abstracts: J Food Process Technol

Abstract:

In this work Crystalline Nano Cellulose (CNC) was isolated from banana pseudostem waste by acid hydrolysis method and Tetracycline (TC) loaded nanocomposite was developed by crosslinking with (Butane Tetra Carboxylic Acid) BTCA and chitosan. Thus obtained CNCs were found to have nanoscopic dimension (18.79ï?±5.30 nm diameter and 202.12ï?±37.43 nm length) and exhibited high degree of crystallinity (81.67%). Morphological study and chemical characterization of CNCs were performed by Scanning Electron Microscopy (SEM), Fourier Transmission Infra-Red (FT-IR) spectroscopy, Thermo gravimetric analysis (TGA) and X-Ray Diffraction (XRD). Nanocomposites were prepared by four different modification methods by crosslinking with BTCA and varying concentration of TC and chitosan. Films (0.18ï?±0.01 mm) prepared by solvent evaporation method were casted in acrylic plates and film morphology, mechanical properties and thermal behavior were studied. In vitro release of TC was carried in citrate buffer (pH 5.7) at incubating condition (37 ºC) with constant stirring (100 rpm) and sustained release of up to 16 hours was observed with TC loaded nanocomposite film with modification method. Antibacterial properties of nanocomposite film against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) was investigated. Nanocomposite film (25 mm diameter) with modification method 3 showed highest zone of inhibition for both E. coli (36.3ï?±0.6 mm) and Staphylococcus aureus (39.3ï?±0.6 mm) with TC drug loading (1205 μg) and crosslinking with chitosan. The obtained nanocomposite can potentially be applied in biomedical field for efficient drug delivery and developing transdermal patches. Finding of the present study reveals economic production of biomaterial for medical applications utilizing lingo cellulosic waste.

Biography :

Pratiksha Shrestha has completed her Masters in Food Engineering and Bioprocess Technology from Asian Institute of Technology, Thailand and currently working as Technical Assistant at Department of Food Technology and Quality Control (DFTQC), Nepal. She is also an Executive Committee Member of Nepal Food Scientists and Technologists Association and General Member of Women in Science and Technology. She has many publications globally.

E-mail: pratiksha.shrestha2001@gmail.com