Journal of Blood Disorders & Transfusion

Extensive menorrhagia in a patient with combined deficiency of vitamin K dependent coagulation factors

Hematologists Global Summit 2018

July 13-14, 2018 Sydney, Australia

Peyman Beigi

Alborz University School of Allied Medicine, Iran

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Vitamin K-dependent clotting factors deficiency (VKCFD) is a severe bleeding disorder that has several causes. Here we described a 43 years old woman, presented with severe menorrhagia and was hospitalized several times for this reason. Laboratory analysis revealed a prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as reduced levels of factor II (FII), factor VII (FVII), factor IX (FIX) and factor X (FX). Neither liver disease nor mal-absorption had been detected. Low level of coagulation factors did not show recovery following administration of high doses of vitamin K but had a suitable response to administration of prothrombin complex concentrates (PCCs) and factor eight inhibitor bypassing activity (FEIBA). Further investigation revealed that patient had hyperchylomicronemia, can interfere with vitamin K transporter and therefore result in acquired VKCFD.

Biography :

Peyman Beigi has completed his BSc in Clinical Laboratory Sciences from Alborz University of Medical Sciences (2013-2017). He has been working as Research Assistant in molecular laboratory for approximately 3 years and currently he is working for Dr. Akbar Dorgalaleh and Dr. Mohammad Reza Rezvani at Hematology Department of Iran University of Medical Sciences mainly on rare bleeding disorders including FXIII. He has made contribution to more that 10 scientific projects and have published several papers.

E-mail: Peymanbeigi1373@abzums.ac.ir