Journal of Clinical & Experimental Pharmacology

Expression and polymorphism of MT1 receptor in patients with gastric adenocarcinoma and its relationship with clinicopathological features

3^rd World Congress on Pharmacology

August 08-10, 2016 Birmingham, UK

Ramin Ataee

Mazandaran University of Medical Sciences, Iran

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Gastric cancer accounts 8% of the total cancer cases and 10% of total cancer deaths worldwide. The indoleamine N-acetyl-5- methoxytryptamine, better known as Melatonin, is the principal hormone produced by the pineal gland. Recently, it has been shown for some anti-cancer role for Melatonin in some malignancies as breast and colon cancer; also some protective role for Melatonin in the GI tract has been known for free radical scavenging, anti-mitogenic and apoptotic properties. According to the anti-cancer effects of Melatonin and due to the wide distribution of this neurohormone in GI tract, some proposed physiologic and pharmacologic role for this neurohormone. Following our previous study, which has shown expression of 2 receptor in gastric adenocarcinoma, was initially studied to determine the expression of Melatonin receptor MT1 in tissue samples of adenocarcinoma cancer patients. For this aim, a total of 10 gastric adenocarcinoma patients and 10 normal individuals were selected and examined for MT1 gene expression by real-time PCR also for genotyping and screening of different alleles of MT1 in our samples, and the SSCPPCR procedures were developed. Our results showed interestingly high expression for MT1 receptor in cancer and marginal cancer tissues comparing with normal people. Although, our experiments have shown many relations between MT1 receptor expressions, grade and clinicopathological figures of tumour. SSCP-PCR results have shown a variation between individuals which might be effective on their expression gene patterns. This study concluded for the first time for the expression of MT1 receptor in gastric adenocarcinoma tissues which was in agree with our previous study but with some difference in comparisons between the kind of tissue expression and difference in polymorphisms.

Biography :

Email: raminataee1349@gmail.com