Journal of Nanomedicine & Nanotechnology

Evaluation of organogel nanoparticles as new vehicle for lipophilic compounds

13^th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology

July 24-25, 2017 | Rome, Italy

Sophie Franceschi

Université Paul Sabatier, France

Scientific Tracks Abstracts: J Nanomed Nanotechnol

Abstract:

In recent years, a growing interest has emerged in the development of semi-solid colloidal careers for the delivery of water-insoluble drugs. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Careers (NLC) are example of such systems. As an alternative to SLN, we propose the use of an original family of organogel nanoparticles. Organogels are semi-solid materials in which an organic solvent (e.g., vegetable oil) is entrapped in the three-dimensional fibrous network formed by self-aggregation of a low molecular mass organic gelator (12-Hydroxystearic acid). The preparation process of the gelled oil nanoparticles is based on the sol-gel phase transition of the organogel obtained by hot emulsification (T°>T°gel) in presence of an aqueous solution of stabilizing agent (Polyvinylalcohol 80), leading to a stable semi-solid dispersion after cooling (T°

Biography :

Sophie Franceschi has her expertise in chemical and physicochemical studies of organized molecular systems for drug delivery and material applications. She has 20 years of experience in research and teaching. She graduated with a PhD from the Paul Sabatier University of Toulouse (France) in 1997 and has a Master’s degree in Molecular and Supramolecular Chemistry. Currently, she is Researcher in SMODD group in the IMRCP Laboratory at the University Paul Sabatier of Toulouse and also Teacher at Paul Sabatier University.

Email: sfrances@chimie.ups-tlse.fr