Biochemistry & Analytical Biochemistry

Evaluation of nephrotoxicity induced by chemotherapy with salts platinum between Cockcroft-Gault method and MDRD method

International Conference on Biochemistry

October 10-12, 2016 Kuala Lumpur, Malaysia

Ibtissem Kihel

Sidi Bel Abbes University, Algeria

Posters & Accepted Abstracts: Biochem Anal Biochem

Abstract:

The platinum salts are one of the most chemotherapy drugs used in cancer (particularly in the lung, bladder, testis, ovary, cervix, endometrial, colon and rectum), however they have a potential renal toxicity requiring an evaluation of tolerance kidney patients before and after treatment cures. This study compares the different methods of assessing renal function used for patients receiving chemotherapy with cisplatin or carboplatin (between the measurement of plasma urea, and the calculation of creatinine clearance as well as changes in the methods of estimating creatinine clearance with the Cockcroft-Gault method and the MDRD method Modification of Diet in Renal Disease). The study was performed on 25 male patients aged 42-74 years admitted to the Oncology Department of the University Hospital Oran for treatment of various cancers, mainly lung cancer. After the spectrophotometric determination of plasma creatinine and urea, the creatinine clearance was calculated by the methods of Cockcroft-Gault and MDRD, the distribution of the urea after the platinum salt of cure is essentially inside the reference interval with an average of (0.38 and 0.36 g/l) after the first treatment and cure 2nd respectively, while the clearance of creatinine is below the range with an average of (69.28 and 72.25 ml/min) after the 1st and 2nd cure respectively, we see that for older patients over age 65 underestimation clearance calculated by Cockcroft-Gault, however it is overestimated by the same method in patients weighing more than 70 kg. Indeed, the evaluation of nephrotoxicity cannot be done on a simple determination of urea or plasma creatinine, but it requires the calculation of creatinine clearance by Cockcroft-Gault or MDRD methods depending on the age and patient weight.

Biography :

Email: kihelibtissem@hotmail.fr