Journal of Stem Cell Research & Therapy

Endogenous stem cells as a treatment for celiac disease, a case report

5^th International Conference and Exhibition on Cell and Gene Therapy

May 19-21, 2016 San Antonio, USA

Henry E Young and Asa C Black

Regeneration Technologies, USA
University of South Carolina, USA

Posters & Accepted Abstracts: J Stem Cell Res Ther

Abstract:

A 59-year old male presented with abdominal discomfort, diarrhea, headaches, fatigue, and bone and joint pain of long standing duration. Underlying complications included Hashimotoâ??s thyroiditis, Sjögrenâ??s disease, autoimmune induced insulin-dependent diabetes, and systemic lupus erythematosus. A sheep red blood cell agglutination test was utilized to detect a numerical value for antibodies to serum-containing antigens. A value of >1.0 designates sufficient circulating immunoglobulins to an antigen to cause an allergic response to that antigen. Based on a value of 73 to the gluten antigen, gliadin, a diagnosis of Celiac disease was made. Between 2011 and the present the patient was placed on a gluten-free diet and treated with 8 endogenous totipotent stem cellpluripotent stem cell transplants, i.e., one autologous, one autologous/allogeneic, three chimeric/allogeneic, and three chimeric. The stem cell transplants entailed daily ingestion of a nutraceutical to stimulate endogenous stem cell proliferation in situ and ingestion of a second nutraceutical prior to harvest to maximize endogenous stem cell capture. The endogenous stem cells were then harvested and segregated by size and unique cell surface markers into individual populations of totipotent stem cells and pluripotent stem cells. The endogenous stem cells were activated and infused systemically into directed sites. Following the 8th stem cell treatment an agglutination test for the gluten antigen gliadin was performed and demonstrated a numerical value of 0.01. As shown, endogenous totipotent stem cell-pluripotent stem cell transplants can modulate the immune system, reversing allergic symptoms in persons with an allergy to gluten.

Biography :

Email: young.hey1@yahoo.com