Clinics in Mother and Child Health

Emerging multi-drug resistant bacterial strain in Neonatal Intensive Care Unit (NICU)s in a developing country-Bangladesh

28^th World Congress on Neonatology & Diagnosis

December 06-07, 2018 | Amsterdam, Netherlands

Aftab Yusuf Raj

Square Hospitals Ltd, Bangladesh

Scientific Tracks Abstracts: Clinics Mother Child Health

Abstract:

Background: Neonatal sepsis remains a major health problem in any NICU worldwide. As, compared to developed countries, the use of antimicrobials in Bangladesh is less regulated and enough data are not available. Aim: The aim of the study was to determine the causative bacteria and the level of their resistance to commonly used antibiotics in NICUs of Bangladesh. Materials & Methods: A total of 1724 blood samples were analyzed (culture and sensitivity tests) from neonates from three major referral NICUs of Bangladesh, who were clinically diagnosed as sepsis. Only culture-positive sepsis was included in the study. Result: Among total, 363 (21.05%) culture positive sepsis, gram negative and gram positive bacteria were found in 88.15% (n=320) and 11.84% (n=43) respectively. Acinetobacter was the most frequent (40.22%) isolated gram negative organism followed by Klebsiella pneumoniae (32.5%), Escherichia coli (7.3%) and Pseudomonas (3%). Overall, 78% of the isolates were multidrug-resistant (68% of gram-positive bacteria and 85.4% of gram-negative bacteria) against commonly used antibiotics such as ampicillin, amoxicillin, cefotaxime, ceftriaxone, gentamicin, linezolid and vancomycin. This study found new emerging bacteria-Burkholderia cepacia (n=5) and Stenotrophomonas maltophilia (n=4), which were both multidrug-resistant and only sensitive to meropenem and colistin respectively. Conclusions: Very high percentage of multi drug resistance to the commonly used antibiotics including emerging multi drug resistant Burkholderia cepacia and Stenotrophomonas maltophilia in NICUs in Bangladesh is alarming and challenge to the management of neonatal sepsis. Continuous surveillance for antibiotic susceptibility is needed to ensure proper empirical therapy.

Biography :

Aftab Yusuf Raj is a Medical Graduate (MBBS) from Sher-e-Bangla Medical College under Dhaka University and obtained MD (Pediatrics) from Bangladesh Institute of Child Health (BICH) and MD (Neonatology) from Bangabandhu Sheikh Mujib Medical University, Bangladesh. Afterwards, he has completed his training from All India Institute of Medical Science (AIIMS) and Fellowship in Neonatology from Colgery Medical University and Alberta Children Hospital, Canada. He has experience in teaching and conducting post-graduation examinations of Bangladesh and also registered by Canadian Royal College of Physicians and Surgeons. Many articles have been published under his name in different national and international medical journals

E-mail: nazma.kamal@sanofi.com