Karl Philipp Puchner
German Leprosy and TB Relief Association, Germany
Scientific Tracks Abstracts: J Trop Dis
Statement of the Problem: After introduction of the groundbreaking Multi-Drug Therapy (MDT) in the early 1980s, WHO
pushed for the elimination of leprosy by 2000. However, despite intensive efforts over 3 decades and undisputable progress,
elimination of leprosy as a public health problem (PHP) at global level is still beyond reach. In this paper we review the
epidemiological dynamics of leprosy, the control strategies applied in the past as well as their evolution and adjustment to
the new state of evidence. Furthermore, inherent challenges and remaining obstacles in the undertaking of leprosy as a PHP
are analyzed. Finally, taking the gradual shift towards integrative health policies and practices into account, we reflect on the
meaningfulness and timeliness of the set elimination targets for leprosy and other Neglected Tropical Diseases (NTDs).
Methodoly: Critical review of articles both on related operational research and basic science, opinion papers and epidemiological
data on leprosy and other NTDs.
Findings: While trends in detection of new cases exhibit a plateau in the last decade, there is evidence of ongoing leprosy
transmission in endemic settings. MDT has made enormous progress possible, yet seems to be insufficient for achieving the
final push. Other recent innovations, though contributing further to the control of leprosy, are unlikely to lead alone or
combined to elimination, as lack of basic biomedical tools and critical knowledge gaps remain. Emerging evidence about
animal reservoirs, regional re-emergence and MDT resistance complicate further the feasibility of near-term elimination
of leprosy. Universal health coverage and integrative medicine undoubtedly strengthen NTDs control ultimately, yet may
jeopardize near-term disease specific elimination milestones.
Conclusions: Despite undeniable progress, near-term achievement of leprosy elimination as a PHP remains unlikely. In face
of the pursuit of horizontal approaches in global health, meaningfulness of individual NTDs elimination targets might need
critical reevaluation.
Karl Philipp Puchner is a physician specialized in internal medicine and has a master’s degree in “International health” from the Institute of Tropical Medicine and International Health in Berlin. Since 2015, he is working as a medical advisor for the German Leprosy and Tb Relief Association (GLRA) and since August 2017 as a medical coordinator of Médecins du Monde, Greece. During his career, he has acquired experience and skills, among others, in the fields of internal medicine, tropical medicine -particularly NTDs and TB - public health, refugee and migrant health as well as epidemiological research.
E-mail: karl.puchner@gmx.de