Journal of Clinical Research & Bioethics

Effects of hesperidin supplementation on weight, glycemic control, lipid profile and inflammatory factors in patients with type 2 diabetes: A randomized, double-blind and clinical trial placebo-controlled

3^rd International Conference on Advanced Clinical Research and Clinical Trials

September 20-21, 2017 Dublin, Ireland

Shahryar Eghtesadi, Mohammad Mohammadi, Mohammadreza Vafa Hossein Khadem Haghighian, Iraj Heydari, Masoud Salehi, Fatemehsadat Amiri, Rooya Alipour and Maryam Eghtesadi

Azad University Science and Research Branch, Iran

Scientific Tracks Abstracts: J Clin Res Bioeth

Abstract:

This study was conducted to investigate the effects of hesperidin (a common constituent of citrus fruits) supplementation on weight, indices of glycemic control, insulin resistance, lipid profile, and inflammatory markers in patients with type 2 diabetes. 45 patients participated in this randomized, double-blind controlled clinical trial who were randomly assigned to 2 intervention and control groups. Participants consumed either 500 mg/d pure hesperidin supplement or placebo in the intervention and control groups for eight weeks, respectively. Hesperidin supplementation led to significant decrease in fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) (p=0.041 and p=0.028, respectively). A significant increase in serum insulin (p=0.018) and decrease in total cholesterol (p=0.049) were also observed in the hesperidin group, whereas no significant changes occurred in the placebo group. Inflammatory factors, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were not significantly changed in the hesperidin group compared to the control group. In conclusion hesperidin supplementation lowered the plasma level of total cholesterol and improved glycemic control and insulin resistance in patients with type 2 diabetes.

Biography :

Shahryar Eghtesadi received Bachelor degree in Nutrition Science and Food Chemistry in 1975, from Shahid Beheshti University of Medical Sciences, Tehran; MSPH degree in Nutrition, 1977, from Tehran University of Medical Sciences, Tehran and PhD from University of California at Davis (UCD), USA, in Nutrition (1985). He served as Visiting Scientist in USDA Human Nutrition Research Center on Aging (HNRCA), Boston, USA (1994-1995); Full professor of Tabriz, Iran and Tehran Universities of Medical Sciences and currently serves as Professor of Azad University, Science & Research Branch. He served as Associate Dean and Dean of School of Public Health & Nutrition and School of Public Health of Tabriz and Iran University of Medical Sciences respectively. He was selected as distinguished Professor and Scientist.