Journal of Microbial & Biochemical Technology

Effect of Staphylococcus aureus PSMα3 toxin on Human Platelets

5^th International Conference on Microbial Physiology and Genomics

September 29-30, 2016 London, UK

Sultan Fahad Alnomasy

University of Reading, UK

Posters & Accepted Abstracts: J Microb Biochem Technol

Abstract:

Community-Associated MRSA (CA-MRSA) is serious human pathogen because its ability to resist and evade the host immune defences and is commonly antibiotic resistance. In the last decade, CA-MRSA infection has become a major worldwide problem and causes a significant increase in the rate of human mortality. Skin and soft tissues are the most common sites for CA- MRSA infections, but CA-MRSA also has the ability to cause acute infections such as meningitis, myositis and endocarditis due to production of toxins such as Phenol-Soluble Modulins (PSMs) which are considered as an important virulence factor of CA-MRSA. PSMs are detected via formyl peptide receptors that are found on immune cells. PSMs toxins play important roles in pathogenesis of S. aureus through attack the innate immune of the host cells and inhibit their functions. Other researchers have also found PSMs to be powerful chemoattractants for neutrophils. This research aims to study the effect of Staphylococcus aureus phenol-soluble modulins α3 (PSMα3) toxin on human platelet activity, what effect S. aureus PSMα3 have on platelet functions and to identify the mechanism of interaction between S. aureus PSMα3 and human platelets.The experimental data from this study show that Staphylococcus aureus PSMα3 toxin to be an inhibitor of platelet activation via increasing the levels of cAMP that activate the PKA which enhances the inhibitory mechanism in platelets that prevents any further activation of platelets.

Biography :

Email: S.F.S.Alnomasy@pgr.reading.ac.uk