Journal of Clinical & Experimental Pharmacology

Effect of herbal bioenhancer “Trikatu” on pharmacokinetics of cefepime following intramuscular administration in cross-bred calves

World Congress on Pharmacology

July 20-22, 2015 Brisbane, Australia

Neetu Rajput and Rajendra Gajanan Ghumde

Posters-Accepted Abstracts: Clin Exp Pharmacol

Abstract:

To study the effect of herbal bio-enhancer ?Trikatu? on pharmacokinetics of cefepime following intramuscular administration in healthy cross-bred calves, cefepime was administered by single intramuscular dose of 10 mg.kg`-1 body weight either alone or along with co-administration of Trikatu at the dose of 2 gm. kg`-1 b.wt. orally. Following single i.m. administration of cefepime along with co-administration of Trikatu, the peak plasma concentration of cefepime was significantly higher (20.4�0.45 ?g.ml-1) than the peak plasma concentration obtained after the administration of cefepime alone (18.5�0.31 ?g.ml-1) at 45 min. The mean value of area under the first moment of plasma drug concentration-time curve (AUMC) was significantly increased (307.8�11.8 ?g.ml-1.h2) when Trikatu was co-administered with cefepime as compared to AUMC (252.5�3.24 ?g.ml-1.h2) when cefepime was administered alone. There was significant reduction in the mean values of B, ? and ClB for cefepime following co-administration with Trikatu (18.7�0.59 ?g.ml-1, 0.247�0.01 h-1 and 0.151�0.01 L.kg- 1.h-1 respectively) as compared to the value (22.3�0.49 ?g.ml-1, 0.296� 0.001 h-1 and 0.179�0.001 L.kg-1.h-1 respectively) obtained after administration of cefepime alone. The mean value of t1/2? (2.83�0.10 h) was significantly higher when Trikatu co-administered with cefepime in cross-bred calves as compared to the t1/2? (2.34�0.01 h) obtained after administration of cefepime alone. The co-administration of Trikatu with cefepime significantly reduced the i.m. loading and maintenance dosage (11.2 mg.kg-1 followed by 10.6 mg.kg-1 b. wt. at 12 h intervals) when Trikatu is co-administered with cefepime in healthy cross-bred calves as compared to i.m. administration of cefepime alone (17.2 mg.kg-1 followed by 16.7 mg.kg-1 b. wt. at 12 h intervals).