Brain Disorders & Therapy

Effect of Helicobacter pylori eradication in elderly patients blood ammonia level and mental function scores

7^th International Conference on Neurological Disorders & Stroke

September 20-21, 2018 | Rome, Italy

Nany Hasan El Gayar, Mohamed Gad, Akram Deghady and Amr Salamah

Alexandria University, Egypt

Posters & Accepted Abstracts: Brain Disord Ther

Abstract:

Aim: We aim to study blood ammonia level and its effect on mental functions in non-hepatic non-renal elderly patients having H.pylori gastritis before and after eradication of infection. Materials & Methodology: The study was carried out on 30 elderly patients having H.pylori gastritis with normal liver and kidney functions. We tested for H.pylori stool antigen using a quantitative monoclonal ELISA assay before and 4 weeks after the treatment to confirm eradication. Patients received 14-days course of Clarithromycin-based triple therapy, which consists of Clarithromycin 500 mg twice daily, Amoxicillin 1000 mg twice daily, and Omeprazole 40 mg twice daily, for H.pylori eradication. Blood ammonia levels were measured before and after infection eradication. Mental functions assessments were done before and after infection eradication using the Mini-Mental State Examination (MMSE) and the Cognitive Assessment Scale for the Elderly (CASE). We compared and studied the correlation between the blood ammonia levels and the mental function scores before and after infection eradication. Data were subjected to computer statistical analysis using IBM SPSS software package version 20.0. Data was normally distributed. Comparisons were done, using paired t-test, between before and after treatment blood ammonia levels, MMSE scores and CASE scores. Correlations of blood ammonia level with MMSE and CASE scores were assessed using Pearson coefficient. Significance of results was judged at 5% level. Results: There were significant reduction of blood ammonia level and improvement of mental function scores after the treatment. There were significant negative correlations between the blood ammonia level and the mental function scores before and after the treatment. There was a significant correlation between the change in blood ammonia level and the change in mental function scores after adjustment for age and sex. Conclusions: Eradication of H. pylori is associated with improvement in blood ammonia level and mental function scores in non-hepatic non-renal elderly patients.

Biography :

E-mail: dr_nany_hasan@yahoo.com