Pharmaceutica Analytica Acta

Effect of crystal imperfection on the performance of pharmaceutical products

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Ibrahim El-Bagory

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Pharmaceutical industry is having great competition between drug producing companies. The quality, performance and efficacy of good competing pharmaceutical products should be kept high from one batch to another. In the pharmaceutical industry, the effects of crystal defect are particularly important in the manufacture of tablets and granules, in the filling of hard-shell gelatin capsules and in powder handling in general. The phenomena and mechanisms involved during compaction of pharmaceutical materials have become an important concept in the design and development of solid dosage forms. The parameters monitored during compaction vary widely in these studies. Data obtained from the measurements of forces on the punches and the displacement of the upper and lower punches, axial to radial load transmission, die wall friction, ejection forces, temperature changes, in-vitro and in-vivo drug release and other miscellaneous parameters have been used to assess the compaction behavior of a variety of pharmaceutical powders and formulations.