Brain Disorders & Therapy

Effect of COC, hypertension, dyslipidemia and susceptibility on the risk of female Stroke in China

Global Summit on Stroke

August 03-05, 2015 Birmingham, UK

Ying Li, Yang Zhao and Jianling Bo

Scientific Tracks Abstracts: Brain Disord Ther

Abstract:

Purpose: To clarify the effect of COC, hypertension, dyslipidemia and susceptibility on the risk of female stroke in order to
decrease the risk of female stroke in China.
Method: This was a population-based multicenter case control study. A prospective cohort study was undertaken in 25 towns
in two counties in Jiangsu Province, China. Women (44408) on COC user and 75230 women with an intrauterine device (IUD)
were followed up for the incidence of stroke. The incident cases of stroke (including cerebral infarction, cerebral hemorrhage
and subarachnoid hemorrhage) identified by computerized tomography (CT) or nuclear magnetic resonance (NMR). Two
different controls including hospitalized patients and neighborhood were matched to the cases according to age ±3 years;
residence and similar date of admission for hospitalized patients. Body weight, height, waist circumference (WC), blood
pressure, serum lipids and apolipoproteins were measured. Polymerase chain reaction (PCR) was used to amplify polymorphic
gene regions for the genotyping of ACE I/D and ACE 2350. The primers and enzyme of AGTA-20C were designed by the PIRA
PCR method. Genotyping of 3 SNPs (rs700651, rs10958409 and rs1333040) was performed by the polymerase chain reaction
assay with TaqMan probes.
Results: There is an increased risk of haemorrhagic stroke among Chinese users of long-term low-dose oral contraceptives
which appears to persist long after discontinuation. The risk of hypertension gradually increased with the increasing cumulative
time of COC use in women (P=0.0043), dyslipidaemia, accumulative time of COC use ≥15 years and their interaction
increased the risk of hypertension. Hypertension was a most important risk factor for stroke incidence. The D allele of ACEI/D
polymorphism may be a potential risk allele for stroke. COC users carried the ID+DD genotype that may further increase the
risk of stroke especially for hemorrhagic stroke. Our results confirmed the associations of two GWAS SNPs (rs10958409 and
rs1333040), moreover, the risk of hemorrhagic stroke increased by 4.81 and 15.06-folds when risk allele carriers of rs10958409
or rs1333040 who took COC. The study assessed the associations of three PAI-1 SNPs and also suggested combined effects of
these PAI-1 gene variants and COC use on stroke risk in the Han Chinese women.
Conclusions: The research results have promoted the understanding of the important high risk factors of Chinese female
stroke and provide evidence to formulate proper prevention measures for coping with the challenges of and an increased
incidence of female stroke.

Biography :

Ying Li is a Professor at Nanjing Medical University School of Public Health. She has completed over 20 granted studies in reproductive and pharmaceutical
epidemiology with over 100 papers and several patents. She studied at CDC under WHO scholarships on reproductive health surveillance and post market
surveillance for the safety of drugs in 1996 and 2000. She has received dozens awards and professional honors and serves as Associate Editor for three
professional journals.