Journal of Stem Cell Research & Therapy

Early immunotherapy using autologous adult stem cells reversed the effect of anti-pancreatic islets in recently diagnosed type 1 diabetes mellitus: Preliminary results

3^rd International Conference and Exhibition on Cell & Gene Therapy

October 27-29, 2014 Embassy Suites Las Vegas, USA

Alejandro Mesples, Nasir Majeed, Yun Zhang and Xiang HuDiabetes Education and Research, Argentina

Accepted Abstracts: J Stem Cell Res Ther

Abstract:

Background: Bone marrow stem cell treatment has been proven a promising therapeutic strategy and showed significant results given the strong immune modulating properties. We have investigated the safety and efficacy of autologous bone marrow stem cell transplantation through liver puncture in two patients with recently diagnosed type 1 diabetes mellitus. Material/Methods: The procedure was approved by the Institutional Ethics Committee. In 2011, in three young patients, type 1 diabetes mellitus diagnosis was confirmed, with the presence of positive antibodies and ketoacidosis. Two patients were treated with autologous bone marrow stem cell stimulated with filgrastim and transplantation, through liver puncture, as immune modulators. One patient was treated with conventional treatment and participated in this experiment as a control group. The families of the patients signed the informed consent. No specific statistical analysis was performed. The patients had less than 8 years old, diagnosis of type 1 diabetes for less than 60 days, body mass index less than 22 kg/m2, normal complete blood count, coagulation and renal function, no lesions in target organs, glycosylated hemoglobin (HbA1c) level less than 13.70%, c-peptide level less than 0.67 ng/ml, positive results of Islets Cells Antibody (ICA), Glutamic Acid Decarboxylase (GAD) and insulin antibody. Results: In two patients who were treated, the follow up at 12 months showed negative value in ICA, GAD and anti insulin antibody levels, with an increased levels of c peptide and decreased levels of blood glucose and HbA1c. Conclusions: Treatment with autologous bone marrow stem cells is easy and effective as it reversed the production and effect of anti pancreatic islet antibody and significantly resulted in an increased c-peptide concentration.

Biography :

Alejandro Mesples, is a Interventional Cardiologist, is an interventional cardiologist, he conducted his post graduate studies at the University Louis Pasteur in Strasbourg, France, and the University of Barcelona, Spain. He completed preclinical and clinical research on the use of bone marrow stem cells in chronic and newly diagnosed diabetics patients for the Ministry of Health of Argentina and Biotech Companies in USA. Currently working with the Institute of Tissue Engineering in Shenzhen Beike, China.