Health Care : Current Reviews

Dwelling the cornea case series on pheripheral ulcerative keratitis

30^th Global Healthcare Summit

March 14-15, 2024 | London, UK

Gadikota Mounika

Sankar Foundation Eye Hospital, India

Posters & Accepted Abstracts: Health Care Curr Re

Abstract:

Purpose: To report a series of patients diagnosed with peripheral ulcerative keratitis (PUK) in our center and describe our practice, as also associated conditions, complications and outcomes. Methods: Retrospective observational study of patients diagnosed with PUK, Outcome was assessed by final visual acuity (VA) and course of extraocular features. A descriptive analysis was performed. Results: Fourteen eyes of 11 patients. In 8 (73%) of them there was an underlying autoimmune disease, the most frequent of which was rheumatoid arthritis (5 out of 8 patients), while no cause was found in the other 3 (27%). Considering therapeutic management, only one patient was well controlled with topical treatment, whereas the remaining 10 patients received systemic intensive therapy, including corticosteroid pulses in 45% and cyclophosphamide in 18% of cases. Surgical treatment with amniotic membrane transplantation was required in 4 patients and a superficial lamellarkeratoplasty (SALK) in one. Average follow-up was 20 ± 15 months. All patients maintained a good VA atthe end of follow-up: Conclusion: PUK is a sight threatening condition which needs both a close multidisciplinary monitoring and an intensive treatment in order to achieve a favorable response. At detection, a diagnostic workup to rule an underlying autoimmune disease should be carried out. A prompt recognition and control of the inflammatory reaction appears decisive for a favorable outcome.