Journal of Bioequivalence & Bioavailability

Dissolution enhancement of felodipine by solid dispersion technique

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Murali Monohar Pandey, Prathyusha Reddy CH, Dhananjay Singh, Shrikanr Charde

Posters: J Bioequiv Availab

Abstract:

F elodipine (FLD) is an Anti-hypertensive drug, an calcium- channel blocker (CCB) of the dihydropyridine (DHP) class. Polymers used for the solid dispersion (SD) were Polyvinylpyrrolidone K-30 (PVP K-30) and Polyethyleneglycol 6000 (PEG 6000) in different ratios. Solvent Evaporation method was used in the preparation of the solid dispersions with PVP K-30. For this, FLD and PVPK- 30 in ratios of 1:2 and 1:4 were dissolved in minimum required volume of ethanol and it was kept on water bath at 40-45?C till the complete evaporation of ethanol occurred. Another technique of kneading was used for the preparation of FLD & PEG-6000 solid dispersion (1:1 & 1:2), wherein homogenized paste was prepared with ethanol and was allowed to continuous kneading for 30-45 min. The solid dispersions thus prepared were characterized by differential scanning calorimetery (DSC) and fourier transform-infrared spectroscopy (FT-IR). Physical mixtures (PM) of the same ratios were also prepared. The dissolution studies of PM and SD were conducted in phosphate buffer (pH 6.8). The samples were analyzed on UV-Visible spectrophotometer at 363 nm wavelength. Felodipine being a poorly water soluble drug, its dissolution enhancement is crucial for the formulation development. It was observed that there was an increase in dissolution of Felodipine with the increase in the ratio of both polymers particularly greater in the case of 1:4 with PVP K-30 and 1:2 with PEG 6000. Thus, solid dispersions could be a extremely helpful for enhancement of dissolution and thereby prospectively aid in better Bioavailability.