Oral Health and Dental Management

Detection of Helicobacter pylori in oral lesions

3^rd Euro Congress and Expo on Dental & Oral Health

June 16-18, 2015 Alicante, Spain

Soussan Irani1, Alireza Monsef Esfahani2 and Farahnaz Bidari Zerehpoush3

Posters-Accepted Abstracts: Oral Health Dent Manag

Abstract:

Background and aims. Helicobacter pylori is a microaerophilic gram-negative spiral organism. It is recognized as the etiologic factor for peptic ulcers, gastric adenocarcinoma and gastric lymphoma. Recently, it has been isolated from dental plaque and the dorsum of the tongue. This study was designed to assess the association between H. pylori and oral lesions such as ulcerative/inflammatory lesions, squamous cell carcinoma (SCC) and primary lymphoma. Materials and methods. A total of 228 biopsies diagnosed as oral ulcerative/inflammatory lesions, oral squamous cell carcinoma (OSCC) and oral primary lymphoma were selected from the archives of the Pathology Department. Thirty-two samples that were diagnosed as being without any pathological changes were selected as the control group. All the paraffin blocks were cut for hematoxylin and eosin staining to confirm the diagnoses and then the samples were prepared for immu-nohistochemistry staining. Data were collected and analyzed. Results. Chi-squared test showed significant differences between the frequency of H. pylori positivity in normal tissue and the lesions were examined (P=0.000). In addition, there was a statistically significant difference between the lesions examined (P=0.042). Chi-squared test showed significant differences between H. pylori positivity and different tissue types ex-cept inside the muscle layer as follows: in epithelium and in lamina propria (P=0.000), inside the blood vessels (P=0.003), inside the salivary gland duct (P=0.036), and muscle layer (P=0.122). Conclusion. There might be a relation between the presence of H. pyloriand oral lesions. Therefore, early detection and eradication of H. pylori in high-risk patients are suggested.

Biography :

Soussan Irani is an assistant professor of oral & maxillofacial pathology 2002 to present currently teaching oral pathology, oral histology, oral embryology and oral biology, and basic pathology. she received her dds from ferdowsi university, mashad , iran, diploma in tropical medicine & public health, also awarded PhD at Griffith university