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Detection of breast cancer using functionalized Fe-Au nanomaterial synthesized using novel method
5th International Conference on Nanotek & Expo
November 16-18, 2015 San Antonio, USA
Sourabh M Mehta, Janhavi A Khanolkar and H Muthurajan
University of Mumbai, India
Posters-Accepted Abstracts: J Nanomed Nanotechnol
Abstract:
Magnetic nanomaterials due to their physicochemical properties have arsenal of applications in fields of biology and medicine such as magnetic targeting, magnetic resonance imaging, immunoassays, RNA and DNA purification and cell separation and purification. The interplay between nanomaterials and biological systems forms an emerging research field of broad importance. In the recent time, magnetic nanomaterials have received attention because of its tunable super magnetic property. With surface modification, nanomaterials can be functionalized using biomolecules, like antibodies. With advantage of tunable magnetic properties, one can purify protein or biomaterial and can also quantify using SPR properties of nanomaterial. In this study, we have synthesized iron oxide-gold nanoparticles using novel route and characterized using Scanning Electron Microscopy (SEM), UV visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR) and X- ray Diffraction (XRD). The elemental and oxidation states of nanoparticles were investigated using X-ray photoelectron spectroscopy (XPS). In further study, a novel Fe-AnNP functionalized using folic acid. As folic acid specifically binds to breast cancer marker which can be pulled down using magnetic field applied in specific direction. This system can isolate breast cancer cells with least possible time and lowest sample required volume. We expect that the combination of unique structural characteristics and integrated functions of multicomponent magnetic nanoparticles will lead to new opportunities in nanobased disease diagnostics. This study can extrapolate in diagnosing various cancers or other diseases.
Biography :
Email: msourabhmehta@gmail.com