Journal of Bioequivalence & Bioavailability

Design and evaluation of polymeric ocular drug delivery system

2^nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

06-08 June 2011, Las Vegas, USA

Vrushali Kashikar, Indrajeet Gonjari and K. Jayveera

Scientific Tracks Abstracts: JBB

Abstract:

T he objective of the present study was to prepare ocular inserts of Moxifl oxacin. Th e inserts were fabricated by solvent casting technique, with an aim by achieving once a day administration in the treatment of conjunctivitis. Inserts were evaluated for fi lm thickness, weight variation, drug content, percentage moisture absorption and loss. In-vitro drug release studies were done using bi-chambered donar receiver compartment model. Th e optimized formulations were subjected to in-vivo studies using rabbits as an animal model and stability studies to assess the eff ectiveness of the formulations. Finally in-vitro and in-vivo correlation was established. In-vitro drug release data was treated according to zero, fi rst, Korsemeyer Peppas and Higuchi kinetics to access the mechanism of drug release. Formulations were found to be uniform in physicochemical parameter with a fewer variations. Plasticizer was found to infl uence in mechanical properties as well as modify the drug release rate of the fi lms. Prepared ocular inserts exhibited desired release within 24 h and found to be strongly revealing the effi cacy of in vitro-in vivo correlation. From stability studies inserts were remained stable both physically and chemically. No burst eff ect but a prolonged drug release was observed from all formulations. Th us it achieves target such as increased residence time, prolonged drug release, reduction in frequency of administration and may improve the patient compliance