Journal of Bioequivalence & Bioavailability

Design and evaluation of controlled release mucoadhesive microparticles of Clonazepam

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Jaipal A., Shailaja P., Mirza K. and Mukesh K.

Posters: J Bioequiv Availab

Abstract:

T he present study aims at preparation and evaluation of mucoadhesive microparticles containing clonazepam. Clonazepam is a ben zodiazepine derivative which is used as an adjunct therapy for the treatment of partial, absence seizures and in acute control of status epilepticus. Single emulsion solvent evaporation method was employed for the preparation of microparticles. Eudragit? RL 100 and Ethyl cellulose were used as mucoadhesive and controlled release polymers. Different proportions of Eudragit? RL 100 and ethyl cellulose (80:20, 70:30 and 50:50) were used in the preparation of microparticles. The obtained microparticles were evaluated for particle size, drug content, entrapment efficiency, in-vitro drug release and drug-excipient compatibility were also performed. The clonazepam microparticles were porous due to rapid extraction of organic solvent and showed entrapment efficiency up to 37.6%. Particle size of the prepared microparticles ranged between 32.31-42.65 μm. Increase in PVA concentration from 0.5 to 1% w/v resulted in decreased particle size. It has been found that drug release was more sustained with an increase in Eudragit RL 100 proportion. FTIR spectra of drug loaded microparticles did not show any significant interactions between drug and excipients. These controlled release mucoadhesive microparticles prepared can be used as an efficient drug delivery system for nasal and buccal routes.